New strategy blocks chronic lung disease in mice

A new study has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for finding new therapies. Exosomes are tiny compartments released from cells that carry different types of cargo, including inflammatory chemicals called cytokines that can drive lung disease. Source

Researchers develop algorithm to find possible misdiagnosis

Researchers have developed an algorithm that can identify patients who may have been wrongly diagnosed. With the help of digital disease history, the algorithm is able to register disease trajectories that differ so much from normal trajectories that there may be a misdiagnosis. The algorithm has been developed on the basis of data from several hundreds of thousands of COPD patients. Source

Hyaluronan is effective in treating chronic lung disease

Researchers found that inhaling unfragmented hyaluronan improves lung function in patients suffering from severe exacerbation of chronic obstructive pulmonary disease (COPD). Hyaluronan, a sugar secreted by living tissue that acts as a scaffold for cells, is also used in cosmetics as a skin moisturizer and as a nasal spray to moisturize lung airways. Utilized as a treatment, hyaluronan decreased the number of days in the hospital. Source

Drug discovery study identifies promising new compound to open constricted airways

In a preclinical study, researchers identified and characterized 18 new compounds (agonists) that activate bitter taste receptor subtype TAS2R5 to promote relaxation of human airway smooth muscle cells. The cross-disciplinary team found 1,10 phenanthroline-5,6-dione (T5-8 for short) was 1,000 times more potent than some of the other bronchodilator agonists tested, and it demonstrated marked effectiveness in human airway smooth muscle cells grown in the laboratory. Source

New research may explain severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study may contribute to future treatments for COVID-19, among other diseases. Source