Computational evaluation of drug delivery reveals room for inhalers improvement

Increased air pollution in recent years has exacerbated health risks for people who suffer from pulmonary diseases and these dynamics underscore the importance of increasing the efficacy of drug delivery devices that administer active pharmaceutical ingredients to treat respiratory illnesses. Researchers describe developing a computational evaluation of drug delivery through both pressurized metered-dose inhalers and dry powder inhalers to determine how the process can be improved. Source

Cell death discovery could lead to new treatment for COPD

Inhibiting necroptosis, a form of cell death, could yield a new treatment approach for chronic obstructive pulmonary disease (COPD), an inflammatory lung condition also known as emphysema, new research shows. The study revealed elevated levels of necroptosis in patients with COPD. By inhibiting necroptosis activity in the lung tissue of COPD patients the researchers found a significant reduction in chronic airway inflammation and lung damage. Source

Is elevated level of lung protein an early predictor for COPD?

Researcher had previously discovered that the total mucin concentrations in the lungs are associated with COPD disease progression and could be used as diagnostic markers of chronic bronchitis, a hallmark condition for patients with COPD. They now report that one of these mucins, MUC5AC, is more closely and reliably associated with the development of COPD than is its brother, MUC5B. Source