Drug discovery study identifies promising new compound to open constricted airways

In a preclinical study, researchers identified and characterized 18 new compounds (agonists) that activate bitter taste receptor subtype TAS2R5 to promote relaxation of human airway smooth muscle cells. The cross-disciplinary team found 1,10 phenanthroline-5,6-dione (T5-8 for short) was 1,000 times more potent than some of the other bronchodilator agonists tested, and it demonstrated marked effectiveness in human airway smooth muscle cells grown in the laboratory. Source

New research may explain severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study may contribute to future treatments for COVID-19, among other diseases. Source

Healthy muscles are a carrot on a string for healthy lungs

Scientists show effectiveness of carrot-based Japanese herbal medicine called ‘Ninjin’yoeito’ in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Source

Understanding lung infections in patients with cystic fibrosis

For young people with cystic fibrosis, lung infection with Staphylococcus aureus, MRSA, is common and is treated with antibiotics in the hope that this will prevent a decline in lung function. However there has recently been debate over the role S. aureus plays in CF lung disease. Researchers have used a new model of CF lungs which could be used to make better decisions about future use of antibiotics. Source