Mystery solved with math: Cytoplasmic traffic jam disrupts sleep-wake cycles

Mathematicians have identified the principle of how aging and diseases like dementia and obesity cause sleep disorders. A combination of mathematical modelling and experiments demonstrated that the cytoplasmic congestion caused by aging, dementia, and/or obesity disrupts the circadian rhythms in the human body and leads to irregular sleep-wake cycles. This finding suggests new treatment strategies for addressing unstable sleep-wake cycles. Source

Poor sleep can lead to depression in adolescents

Chronic sleep disruption during adolescence can lead to depression in both males and females and alters stress reactivity in females, according to a new study. Their findings are particularly relevant in the context of a pandemic when adolescents’ mental health is already under strain. Source