Sleep, death and … the gut?

A new study finds a causal link between sleep deprivation and death. In sleep-deprived fruit flies, death is preceded by the accumulation of molecules known as reactive oxidative species in the gut. When fruit flies were given antioxidant compounds that neutralize ROS, sleep-deprived flies remained active and had normal lifespans. The findings may one day inform new approaches to counteract the harmful effects of insufficient sleep in humans. Source

How do we disconnect from the environment during sleep and under anesthesia?

A series of new studies finds, among other important discoveries, that noradrenaline, a neurotransmitter secreted in response to stress, lies at the heart of our ability to ”shut off” our sensory responses and sleep soundly. Source

Replacing time spent sitting with sleep or light activity may improve your mood

New research found that substituting prolonged sedentary time with sleep was associated with lower stress, better mood and lower body mass index (BMI), and substituting light physical activity was associated with improved mood and lower BMI across the next year. Source

Proper synaptic joint will get you good night’s sleep

A research team has reported in vivo findings that a certain presynaptic cell adhesion molecule named is crucial for the development of synapses in the developing brain. Source

Sleep difficulties linked to altered brain development in infants who later develop autism

New research finds that sleep problems in a baby’s first 12 months may not only precede an autism diagnosis, but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus. Source

Genetic variation in a brain-cleansing water channel affects human sleep

The reason why we sleep remains an unresolved question of the 21st century. Research now shows that the depth of non-rapid-eye-movement (nonREM) sleep in humans is associated with different genetic versions of a gene that encodes a water channel involved in fluid flow in the brain. Source

‘Loss of pleasure’ found in teen sleep study

Sleep patterns around the world have been disrupted as screen time increases and sleep routines change with COVID-19 self-isolation requirements. Negative mood is not unusual in adolescence, but lack of sleep can affect mental health, causing anhedonia (or loss of pleasure), anxiety, anger and significantly increasing the risk of depression, a global study of more than 350,000 teens shows. Source

Ef­fects of rapid-act­ing an­ti­de­press­ants con­sol­id­ated in sleep?

Ketamine alleviates depressive symptoms within hours, with the most significant change typically seen a day after its administration. However, the symptoms often reappear within a week. According to researchers, neural connections strengthened by the quick treatment of depression are consolidated in the brain during the deep sleep periods of the following night. To prevent the circle of negative thoughts regaining supremacy, depressed patients also need therapy. Source

Link between obesity and sleep loss

Can staying up late make you fat? Researchers found the opposite to be true when they studied sleep in worms: It’s not the sleep loss that leads to obesity, but rather that excess weight can cause poor sleep. Source

Early bedtime may help children maintain healthy weight

Going to bed early and following a consistent bedtime routine may help reduce children’s risk of becoming overweight or obese, according to a new study published in Acta Paediatrica. Source